Trifluoroacetic acid → HCID 131717450、化合物

反応式

NC1SN=C(/[C:7](=N/OCF)/[C:8]([NH:10][C@@H:11]2[C:32](=[O:33])[N:13]3[C:14]([C:29]([O-:31])=[O:30])=[C:15](/[CH:18]=[CH:19]/[CH2:20][N+:21]([CH2:25][C:26](=[O:28])[NH2:27])([CH2:23]C)[CH3:22])[CH2:16][S:17][C@H:12]23)=[O:9])N=1.[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41].[C:45]1(OC)[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1>>[F:38][C:39]([F:44])([F:43])[C:40]([O-:42])=[O:41].[C:45]1([CH2:7][C:8]([NH:10][C@@H:11]2[C:32](=[O:33])[N:13]3[C:14]([C:29]([OH:31])=[O:30])=[C:15](/[CH:18]=[CH:19]/[CH2:20][N+:21]([C@@H:25]([C:26](=[O:28])[NH2:27])[CH3:39])([CH3:22])[CH3:23])[CH2:16][S:17][C@H:12]23)=[O:9])[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=1

参加物

反応物 3

HCID 6422Trifluoroacetic acid

HCID 7519Anisole

HCID 6536774Cefluprenam

生成物 1

HCID 131717450HCID 131717450、化合物

実験手順

In a similar manner as in Example 5, the compound (34.5 g) of Example 14 was suspended in anisole (210 ml), followed by an addition of trifluoroacetic acid (230 ml) to obtain the target compound (25.9 g).

出典と根拠

ORDレコード: ord-b1b3598b01e04618bd12feda8544a772
出典データセット: uspto-grants-1992_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05128465

反応ノート

読み込み中…