Acetic Acid → 3-[2-Butyl-4-chloro-1-(4-aminobenzyl)imidazol-5-yl] propenoic acid ethyl ester

HRID 653930

反応式

HRID 653930 の反応式
[CH2:1]([O:3][C:4](=[O:27])[CH:5]=[CH:6][C:7]1[N:11]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([N+:19]([O-])=O)=[CH:15][CH:14]=2)[C:10]([CH2:22][CH2:23][CH2:24][CH3:25])=[N:9][C:8]=1[Cl:26])[CH3:2].C(O)(=O)C>C(O)C.[Fe]>[CH2:1]([O:3][C:4](=[O:27])[CH:5]=[CH:6][C:7]1[N:11]([CH2:12][C:13]2[CH:14]=[CH:15][C:16]([NH2:19])=[CH:17][CH:18]=2)[C:10]([CH2:22][CH2:23][CH2:24][CH3:25])=[N:9][C:8]=1[Cl:26])[CH3:2]

参加物

5

反応物 2

HCID 176Acetic AcidHCID 536609323-[2-Butyl-4-chloro-1-(4-nitrobenzyl)imidazol-5-yl]propenoic acid ethyl ester

生成物 1

HCID 543706923-[2-Butyl-4-chloro-1-(4-aminobenzyl)imidazol-5-yl] propenoic acid ethyl ester

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 702Ethanol溶媒

実験手順

A mixture of 0.5 g of 3-[2-butyl-4-chloro-1-(4-nitrobenzyl)imidazol-5-yl]-propenoic acid ethyl ester (E isomer) prepared from Part B of Example 227, 1 g of iron and 2 mL of glacial acetic acid in 30 mL of absolute ethanol was refluxed for 1 hour. The reaction mixture was concentrated to dryness and the residue was dissolved in 50 mL of H2O. The aqueous solution was adjusted to pH 8 by K2CO3 and was extracted with ethyl acetate. The crude product obtained upon concentration of the ethyl acetate extract was purified by flash silica gel column chromatography (hexane:ethyl acetate=1:1 elution). The desired compound was obtained as a thick colorless oil, 0.35 g.

後処理

  1. temperaturewas refluxed for 1 hour
  2. concentrationThe reaction mixture was concentrated to dryness
  3. dissolutionthe residue was dissolved in 50 mL of H2O
  4. extractionwas extracted with ethyl acetate
  5. customThe crude product obtained upon concentration of the ethyl acetate
  6. extractionextract
  7. customwas purified by flash silica gel column chromatography (hexane:ethyl acetate=1:1 elution)

出典と根拠

ORDレコード
ord-5e23c20f06524ce8b50b4e5eb517db0f
出典データセット
uspto-grants-1992_07
特許番号
US05128355

関連ノート

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