methyl (E)-3-(3-quinolinyl)-2-propenoate → HCID 11053048、化合物
反応式
[CH3:1][O:2][C:3](=[O:16])/[CH:4]=[CH:5]/[C:6]1[CH:7]=[N:8][C:9]2[C:14]([CH:15]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2>CCOC(C)=O.[Pd]>[CH3:1][O:2][C:3](=[O:16])[CH2:4][CH2:5][C:6]1[CH:7]=[N:8][C:9]2[C:14]([CH:15]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2参加物
4
実験手順
A mixture of (E)-3-(3-quinolinyl)-2-propenoic acid methyl ester (3.6 g, 16.9 mmol) and 5% Pd/C (0.4 g) in EtOAc (300 mL) was hydrogenated at atmospheric pressure. Upon sessation of hydrogen uptake, the catalyst was separated by filtration through a pad of Celite and the filtrate was evacuated to dryness to give the crude product (3.48 g) which was purified via flash chromatography eluting with a mixture of CH2Cl2 and ether (1:1) to give 3-quinolinepropanoic acid methyl ester (2.77 g, 12.9 mmol) in 76% yield as a glass.
後処理
- customUpon sessation of hydrogen uptake, the catalyst was separated by filtration through a pad of Celite
- customthe filtrate was evacuated to dryness
- customto give the crude product (3.48 g) which
- customwas purified via flash chromatography
- washeluting with a mixture of CH2Cl2 and ether (1:1)
出典と根拠
- ORDレコード
- ord-b4f9707a6e1142d6bcfb54e80253646b
- 出典データセット
- uspto-grants-1992_07
- 特許番号
- US05128448
反応ノート
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