Water → HCID 10398790、化合物

反応式

O[C:2]([C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[C:13]([OH:15])=[CH:12][CH:11]=[CH:10]2)([CH3:4])[CH3:3].[OH2:16].N1[CH:22]=[CH:21]C=CC=1>C(O)(=O)C>[C:21]([O:15][C:13]1[C:14]2[C:9](=[CH:8][CH:7]=[CH:6][C:5]=2[C:2]([CH3:4])=[CH2:3])[CH:10]=[CH:11][CH:12]=1)(=[O:16])[CH3:22]

参加物

反応条件

温度: 60 °C

実験手順

11.3 g of 8-(1-hydroxy-1-methyl-1-ethyl)-1-naphthol was dissolved in 24 ml of pyridine, to which 12 ml of anhydrous acetic acid was added. The solution was raised in temperature to 60° C. and heated for 6 hours under agitation. Water was added to the reaction solution, followed by extraction with ethyl acetate. The resulting organic phase was washed with a 2N hydrochloric acid aqueous solution, water and a saturated saline solution in this order, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure. The resultant residue was purified by silica gel column chromatography (10% ethyl acetate/hexane) to obtain 3.6 g of the captioned compound as an oily substance.