Sodium → HCID 14552385、化合物
反応式
[Na].[CH2:2]([O:4][C:5]([CH:7]1[CH:16]([NH2:17])[CH2:15][CH2:14][C:9]2([O:13][CH2:12][CH2:11][O:10]2)[CH2:8]1)=[O:6])[CH3:3]>C(O)C>[NH2:17][C@@H:16]1[CH2:15][CH2:14][C:9]2([O:13][CH2:12][CH2:11][O:10]2)[CH2:8][C@H:7]1[C:5]([O:4][CH2:2][CH3:3])=[O:6]参加物
4
実験手順
Sodium metal (27.7 g, 1.2 mole) was reacted with ethanol (1 1), then ethyl-8-amino-1,4-dioxaspiro-[4.5]-decane-7-carboxylate (137.7 g, 0.6 mole) in ethanol (400 ml) was added. The mixture was refluxed for 11/2 hours, then cooled to room temperature, poured into ice, and made basic. The product was extracted with methylene chloride, dried with sodium sulfate and evaporated to give 118.0 g (85.7%) of the title product.
後処理
- temperatureThe mixture was refluxed for 11/2 hours
- additionpoured into ice
- extractionThe product was extracted with methylene chloride
- dry with materialdried with sodium sulfate
- customevaporated
出典と根拠
- ORDレコード
- ord-612371824e85485db48cb5991954b6bc
- 出典データセット
- uspto-grants-1992_07
- 特許番号
- US05134143
反応ノート
読み込み中…