Water → (2,3-Dihydro-1-benzofuran-2-yl)methanol

HRID 654752

反応式

HRID 654752 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[O:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[CH2:9][CH:8]1[C:16](O)=[O:17].O.[OH-].[Na+]>C(OCC)C>[O:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[CH2:9][CH:8]1[CH2:16][OH:17]

参加物

6

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 27765552,3-Dihydro-1-benzofuran-2-carboxylic acidHCID 21226445Aluminium lithium hydride

生成物 1

HCID 2795428(2,3-Dihydro-1-benzofuran-2-yl)methanol収率 90%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

A three-necked flask is charged with 17 g of lithium aluminum hydride dissolved in anhydrous ethyl ether. 3 g of 2,3-dihydro-2-benzofurancarboxylic acid (Chim. Ler., (1973), 3, p. 259), dissolved in 1,140 ml of ethyl ether, are then introduced. The reaction medium is left stirring overnight. It is then hydrolyzed in an ice bath with 15.2 ml of water, 15.2 ml of 4N sodium hydroxide and then 45.2 ml of water. The complex is drained and washed with ethyl ether and the filtrate is dried and distilled to obtain the expected compound

後処理

  1. additionare then introduced
  2. waitThe reaction medium is left
  3. washwashed with ethyl ether
  4. customthe filtrate is dried
  5. distillationdistilled

出典と根拠

ORDレコード
ord-e7dd00e04394442096bec33f41038b65
出典データセット
uspto-grants-1992_07
特許番号
US05134147

関連ノート

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