Bromomethyl 4-methoxyphenyl ketone → 2-(4-Methoxyphenyl)indolizine

HRID 65478

反応式

HRID 65478 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH3:7].[CH3:8][O:9][C:10]1[CH:19]=[CH:18][C:13]([C:14](=O)[CH2:15]Br)=[CH:12][CH:11]=1>C(O)C.O>[CH3:8][O:9][C:10]1[CH:19]=[CH:18][C:13]([C:14]2[CH:7]=[C:2]3[N:1]([CH:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3]3)=[CH:12][CH:11]=1

参加物

5

反応物 2

HCID 4965Bromomethyl 4-methoxyphenyl ketoneHCID 79752-Methylpyridine

生成物 1

HCID 3469492-(4-Methoxyphenyl)indolizine収率 83.4%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

10 g of 2-picoline and 25 g of 4-methoxyphenacyl bromide in 35 ml of ethanol were refluxed for 18 hours. The reaction solution was concentrated under reduced pressure to give a solid, which was dissolved in 350 ml of water. After the aqueous solution was extracted with three 35 ml portions of ether, 35 g of sodium bicarbonate was added to the aqueous solution and was refluxed two hours. The cooled reaction mixture was filtered to give 20 g of product.

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customto give a solid, which
  3. extractionAfter the aqueous solution was extracted with three 35 ml portions of ether, 35 g of sodium bicarbonate
  4. additionwas added to the aqueous solution
  5. temperaturewas refluxed two hours
  6. customThe cooled reaction mixture
  7. filtrationwas filtered

出典と根拠

ORDレコード
ord-8c6c6592fb4c4d65849b97e47bb9822d
出典データセット
uspto-grants-1986_09
特許番号
US04614801

関連ノート

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