5-(Pyridin-2-yl)pent-4-yn-1-ol → 2-Pyridinepentanol

HRID 654936ノート

反応式

HRID 654936 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]#[C:8][CH2:9][CH2:10][CH2:11][OH:12]>C(OCC)C.[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]

参加物

4

反応物 1

HCID 109973535-(Pyridin-2-yl)pent-4-yn-1-ol

生成物 1

HCID 143474782-Pyridinepentanol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 3283Diethyl Ether溶媒

実験手順

A solution of 5-(2-pyridyl)-4-pentyn-1-ol (1 g, 6.2 mmol) in diethyl ether (15 ml) was hydrogenated over 10% palladium on carbon at room temperature for 16 h. The mixture was filtered through celite and the filtrate on evaporation gave an oil, which was flash chromatographed on silica using 80% ethyl acetate/chloroform. Fractions with Rf of about 0.06 on evaporation gave the title alcohol as a yellow oil.

後処理

  1. filtrationThe mixture was filtered through celite
  2. customthe filtrate on evaporation
  3. customgave an oil, which
  4. customchromatographed on silica using 80% ethyl acetate/chloroform
  5. customFractions with Rf of about 0.06 on evaporation

出典と根拠

ORDレコード
ord-8c36a7b54eb649aeb64e5b8168272bb1
出典データセット
uspto-grants-1992_07
特許番号
US05134128

反応ノート

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