Sodium Hydroxide → (S)-3-benzyloxymethyloxy-2-methylpropionic acid

HRID 654991ノート

反応式

HRID 654991 の反応式
[CH2:1]([O:8][CH2:9][O:10][CH2:11][C@H:12]([CH3:17])[C:13]([O:15]C)=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO.O>[CH2:1]([O:8][CH2:9][O:10][CH2:11][C@H:12]([CH3:17])[C:13]([OH:15])=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 14348497methyl (S)-3-benzyloxymethyloxy-2-methylpropionate

生成物 1

HCID 14348499(S)-3-benzyloxymethyloxy-2-methylpropionic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

Methyl (S)-3-benzyloxymethyloxy-2-methylpropionate (1.20 g; 5 mmole) was dissolved in methanol (12 ml), and a lN sodium hydroxide solution (5.5 ml) was added thereto with ice-cooling, followed by stirring at room temperature for overnight. The reaction mixture was diluted with water (30 ml) and washed with ether (20 ml) two times. The aqueous layer was acidified with 6N hydrochloric acid with ice-cooling and extracted with ethyl acetate (30 ml) three times. The extracts were combined together, washed with water and dried over anhydrous sodium sulfate and concentrated under reduced pressure to give (S)-3-benzyloxymethyloxy-2-methylpropionic acid.

後処理

  1. temperaturewith ice-cooling
  2. washwashed with ether (20 ml) two times
  3. temperaturecooling
  4. extractionextracted with ethyl acetate (30 ml) three times
  5. washwashed with water
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-ffeef2f695554ddfb9bdfc29635e1d2d
出典データセット
uspto-grants-1992_07
特許番号
US05134231

反応ノート

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