Acetic Anhydride → HCID 19886039、化合物

HRID 655051ノート

反応式

HRID 655051 の反応式
[CH3:1][O:2][C:3]1[CH:37]=[CH:36][C:6]([CH2:7][O:8][C:9]2[CH:10]=[C:11](C(OCC3C=CC=CC=3)(O)C)[CH:12]=[CH:13][C:14]=2[O:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=2)=[CH:5][CH:4]=1.[C:38](OC(=O)C)(=[O:40])[CH3:39]>N1C=CC=CC=1>[CH3:24][O:23][C:20]1[CH:21]=[CH:22][C:17]([CH2:16][O:15][C:14]2[C:9]([O:8][CH2:7][C:6]3[CH:36]=[CH:37][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)=[CH:10][CH:11]=[CH:12][C:13]=2[CH:38]([OH:40])[CH3:39])=[CH:18][CH:19]=1

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 67742855HCID 67742855、化合物

生成物 1

HCID 19886039HCID 19886039、化合物収率 91.5%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To an ice cold solution of α-chloro-3,4-dihydroxypropiophenone (2) (1.0 g; 4.98 mMol.) in pyridine (3 ml) is added acetic anhydride (1.2 ml) After 1.5 hours at room temperature, the reaction mixture is concentrated under reduced pressure. The residue is dissolved in chloroform, washed with water, dried, and concentrated under reduced pressure to give α-chloro-2,3-diacetoxypropiopheonen (3) (1.3 g).

後処理

  1. concentrationthe reaction mixture is concentrated under reduced pressure
  2. dissolutionThe residue is dissolved in chloroform
  3. washwashed with water
  4. customdried
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-b20ab1833c8e4b77a941b5b82cc494d5
出典データセット
uspto-grants-1992_07
特許番号
US05134138

反応ノート

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