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HRID 655125作成日：2026年10月26日

phenylalaninol, (S)- → (2R,3R,4S,5R)-2-[6-((S)-1-Benzyl-2-hydroxyethylamino)-2-chloro-purin-9-yl]-5-(2-benzyl-2H-tetrazol-5-yl)-tetrahydro-furan-3,4-diol

https://huagongshe.com/reaction/655125

反応式

関与物質

役割名称HCID仕込み量
反応物phenylalaninol, (S)-HCID 447213—
反応物(2R,3S,4R,5R)-2-(2-benzyl-2H-tetrazol-5-yl)-5-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-tetrahydro-furan-3,4-diolHCID 86645702—
生成物(2R,3R,4S,5R)-2-[6-((S)-1-Benzyl-2-hydroxyethylamino)-2-chloro-purin-9-yl]-5-(2-benzyl-2H-tetrazol-5-yl)-tetrahydro-furan-3,4-diolHCID 86645701—

反応手順

The title compound is prepared in an analogous fashion to (2R,3S,4R,5R)-2-(2-benzyl-2H-tetrazol-5-yl)-5-[2-chloro-6-(2,2-diphenylethylamino)-purin-9-yl]-tetrahydro-furan-3,4-diol (WO 99/38877) by replacing 2,2-diphenylethylamine with (S)-2-amino-3-phenyl-propan-1-ol

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08071565B2
出典データセットuspto-grants-2011_12
ORD IDord-3c269b48a2f8459f96d619355dd99ad8
出典メモuspto-grants-2011_12