3-(2-Pyridyl)-2-cyclopenten-1-one → 3-(2-Pyridyl)cyclopentan-1-one

HRID 655137ノート

反応式

HRID 655137 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH2:11][CH2:10][C:9](=[O:12])[CH:8]=1>CCO.[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]1[CH2:11][CH2:10][C:9](=[O:12])[CH2:8]1

参加物

4

反応物 1

HCID 392355473-(2-Pyridyl)-2-cyclopenten-1-one

生成物 1

HCID 594861153-(2-Pyridyl)cyclopentan-1-one収率 225.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 3-(2-pyridyl)-2-cyclopenten-1-one (1.43 g, 8.98 mmol) and 10% Pd/C (142 mg) in EtOH (30 mL) was stirred under hydrogen atmosphere (0.3 MPa) for 6.5 h. The catalyst was removed by filtration over Celite and the filtrate was concentrated in vacuo. The crude product was purified by column chromatography (Hexane/EtOAc=1/1) to yield 3-(2-pyridyl)cyclopentan-1-one (3.26 g, 94%) as colorless oil.

後処理

  1. customThe catalyst was removed by filtration over Celite
  2. concentrationthe filtrate was concentrated in vacuo
  3. customThe crude product was purified by column chromatography (Hexane/EtOAc=1/1)

出典と根拠

ORDレコード
ord-68742832c65740f2be7f38b4ca104c31
出典データセット
uspto-grants-2011_12
特許番号
US08071591B2

反応ノート

読み込み中…