反応式
Cl.[C:2]([NH:6][CH2:7][C:8]([C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]2[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=2)=[C:12]([O:24][C:25]2[CH:30]=[CH:29][C:28]([CH3:31])=[CH:27][CH:26]=2)[CH:11]=1)=[O:9])([CH3:5])([CH3:4])[CH3:3].Cl.C(N(CCCC)CCCC)CCC.[BH4-].[Na+]>>[C:28]1([CH3:31])[CH:27]=[CH:26][C:25]([O:24][C:12]2[CH:11]=[C:10]([CH:15]=[CH:14][C:13]=2[O:16][C:17]2[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=2)[CH:8]([OH:9])[CH2:7][NH:6][C:2]([CH3:5])([CH3:4])[CH3:3])=[CH:30][CH:29]=1参加物
4
実験手順
The crude products of the foregoing examples containing minor amounts of acid-acceptor amine hydrochloride can be used without further purification in the reduction step to produce the corresponding phenylethanolamine compound. For example, a sample of 3,4-bis(p-toluyloxy)phenyl N-(tert-butyl)aminomethyl ketone hydrochloride containing about 6 percent of tributylamine hydrochloride was reduced with sodium borohydride to give 3,4-bis(p-toluyloxy)-α-[(tert-butylamino)methyl]benzyl alcohol (bitolterol) in greater than 90% yield.
出典と根拠
- ORDレコード
- ord-4380dbd7b8154b2390a8d98f80cae45b
- 出典データセット
- uspto-grants-1986_09
- 特許番号
- US04614830
関連ノート
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