4-Bromo-1-trityl-1H-imidazole → 3-(1H-Imidazol-4-yl)-6-(6-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylmethyl)-quinoline

HRID 655290

反応式

HRID 655290 の反応式
Br[C:2]1[N:3]=[CH:4][N:5](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:6]=1.C([Mg]Br)C.Br[C:31]1[CH:32]=[N:33][C:34]2[C:39]([CH:40]=1)=[CH:38][C:37]([CH2:41][C:42]1[N:46]3[N:47]=[C:48]([CH3:51])[CH:49]=[CH:50][C:45]3=[N:44][N:43]=1)=[CH:36][CH:35]=2>O1CCCC1.[Cl-].[Cl-].[Zn+2]>[NH:3]1[CH:2]=[C:6]([C:31]2[CH:32]=[N:33][C:34]3[C:39]([CH:40]=2)=[CH:38][C:37]([CH2:41][C:42]2[N:46]4[N:47]=[C:48]([CH3:51])[CH:49]=[CH:50][C:45]4=[N:44][N:43]=2)=[CH:36][CH:35]=3)[N:5]=[CH:4]1

参加物

6

反応物 3

HCID 27732744-Bromo-1-trityl-1H-imidazoleHCID 593202953-Bromo-6-(6-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylmethyl)-quinolineHCID 178418443HCID 178418443、化合物

生成物 1

HCID 1784235183-(1H-Imidazol-4-yl)-6-(6-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylmethyl)-quinoline収率 8%

試薬・触媒・溶媒 2

HCID 3007855Zincchloride触媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
70 °C

実験手順

To a solution of 4-bromo-1-trityl-1H-imidazole (103 mg, 0.24 mmol, 1.0 equiv) in tetrahydrofuran (1 mL) was added ethyl magnesium bromide (3M in diethylether, 0.094 mL, 0.28 mmol, 1.2 equiv) and the reaction was stirred for 90 min. ZnCl2 (38 mg, 0.28 mmol, 1.2 equiv) was then added and the solution stirred for an additional 90 min. Tetrakis (triphenylphosphine)palladium (2 mg, 0.024 mmol, 0.10 equiv) and 3-bromo-6-(6-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylmethyl)-quinoline (100 mg, 0.28 mmol, 1.2 equiv) were added and the solution heated at 70° C. for 18 hours. The solvent was removed in vacuo and the residue absorbed onto silica gel and purified by flash chromatography (SiO2, CH2Cl2:CH3OH 100:0-80:20 to return 6-(6-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylmethyl)-3-(3-trityl-3H-imidazol-4-yl)-quinoline. The trityl group was removed by stirring the compound in methanolic hydrochloric acid (0.5 N) for 3 hours. The volatiles were removed in vacuo and the residue stirred in ethanol and collected via filtration and dried to return the title compound (5.6 mg, 8% yield). Analytical data presented in Table 2.

後処理

  1. stirringthe solution stirred for an additional 90 min
  2. customThe solvent was removed in vacuo
  3. customthe residue absorbed onto silica gel
  4. custompurified by flash chromatography (SiO2, CH2Cl2:CH3OH 100:0-80:20
  5. customThe trityl group was removed
  6. stirringby stirring the compound in methanolic hydrochloric acid (0.5 N) for 3 hours
  7. customThe volatiles were removed in vacuo
  8. stirringthe residue stirred in ethanol
  9. filtrationcollected via filtration
  10. customdried

出典と根拠

ORDレコード
ord-8bbf4d1a692f4873a51bd12db44baf90
出典データセット
uspto-grants-2011_12
特許番号
US08071581B2

関連ノート

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