Acetyl chloride → 2-Chloro-alpha-phenyl-3-pyridinemethanol acetate

HRID 65539ノート

反応式

HRID 65539 の反応式
[Cl:1][C:2]1[C:7]([CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[OH:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[C:16](Cl)(=[O:18])[CH3:17].FC(F)(F)C(O)=O>O>[C:16]([O:9][CH:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:7]1[C:2]([Cl:1])=[N:3][CH:4]=[CH:5][CH:6]=1)(=[O:18])[CH3:17]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 6422Trifluoroacetic acidHCID 30619803-Pyridinemethanol, 2-chloro-alpha-phenyl-

生成物 1

HCID 538842082-Chloro-alpha-phenyl-3-pyridinemethanol acetate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 4.39 g 2-chloro-α-phenyl-3-pyridinemetanol (see Ex. 20), 3.14 g acetyl chloride and 8 ml trifluoroacetic acid is stirred for 1 hr. at room temperature. The reaction liquid is added dropwise to water, and the solid formed is filtered, washed, dried and crystallised from cyclohexane. Yield: 4.46 g title product, m.p. 100°-2° C.; Cl 13.82 (13.55).

後処理

  1. customat room temperature
  2. customThe reaction liquid
  3. customthe solid formed
  4. filtrationis filtered
  5. washwashed
  6. customdried
  7. customcrystallised from cyclohexane

出典と根拠

ORDレコード
ord-a6d0157429e44f1384d971730ce61fc6
出典データセット
uspto-grants-1986_09
特許番号
US04614833

反応ノート

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