Methyl (3S,4R)-4-(benzylamino)-3-methylpiperidine-1-carboxylate → Methyl (3S,4R)-4-amino-3-methylpiperidine-1-carboxylate

HRID 655770ノート

反応式

HRID 655770 の反応式
C([NH:8][C@@H:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH3:18])=[O:16])[CH2:11][C@@H:10]1[CH3:19])C1C=CC=CC=1>CO.[H][H].[Pd]>[NH2:8][C@@H:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH3:18])=[O:16])[CH2:11][C@@H:10]1[CH3:19]

参加物

5

反応物 1

HCID 58075022Methyl (3S,4R)-4-(benzylamino)-3-methylpiperidine-1-carboxylate

生成物 1

HCID 58075083Methyl (3S,4R)-4-amino-3-methylpiperidine-1-carboxylate収率 101.6%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 178418361HCID 178418361、化合物溶媒

実験手順

Methyl (3S,4R)-4-(benzylamino)-3-methylpiperidine-1-carboxylate (8.0 g, 0.02 mol) was dissolved in methanol (200 mL) and hydrogenated at room temperature, under 50 psi of hydrogen pressure, in the presence of palladium (2.5 g) on carbon for 2 h. The solution was then filtered and concentrated under reduced pressure to yield 3.5 g (92%) Methyl (3S,4R)-4-amino-3-methylpiperidine-1-carboxylate as liquid.

後処理

  1. filtrationThe solution was then filtered
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-e25b30d485d84329aefc171162f2844d
出典データセット
uspto-grants-2011_12
特許番号
US08071605B2

反応ノート

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