Trifluoroacetic acid → 2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-1-butanamine hydrochloride

HRID 655921ノート

反応式

HRID 655921 の反応式
[Cl:1][C:2]1[C:3]([CH:12]([CH2:22][CH3:23])[CH2:13][NH:14]C(=O)OC(C)(C)C)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.FC(F)(F)C(O)=O>ClCCl>[ClH:1].[Cl:1][C:2]1[C:3]([CH:12]([CH2:22][CH3:23])[CH2:13][NH2:14])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 23078240Tert-butyl 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]butylcarbamate

生成物 1

HCID 667981942-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-1-butanamine hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

146 g of tert-butyl 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]butylcarbamate (0.414 mol) are dissolved in 2 L of dichloromethane. 190 mL of trifluoroacetic acid are added dropwise. The reaction mixture is stirred at room temperature for twelve hours, concentrated to dryness and diluted in 300 mL of hydrochloric acid 2M.

後処理

  1. concentrationconcentrated to dryness
  2. additiondiluted in 300 mL of hydrochloric acid 2M

出典と根拠

ORDレコード
ord-f0997891f17c4e0d81f70f76dd423c90
出典データセット
uspto-grants-2011_12
特許番号
US08071627B2

反応ノート

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