Sodium Hydroxide → HCID 66918073、化合物

HRID 655941ノート

反応式

HRID 655941 の反応式
[Cl:1][C:2]1[C:3]([CH:9]2[CH2:11][CH:10]2[C:12]([O:14]CC)=[O:13])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[C:3]([CH:9]2[CH2:11][CH:10]2[C:12]([OH:14])=[O:13])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 66918072Ethyl 2-(3,5-dichloropyridin-2-yl)cyclopropanecarboxylate

生成物 1

HCID 66918073HCID 66918073、化合物収率 91.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1.65 g of ethyl 2-(3,5-dichloropyridin-2-yl)cyclopropanecarboxylate (0.00634 mol) are dissolved in 20 ml of ethanol, 9.5 ml of sodium hydroxide 1M are added to the reaction mixture which is refluxed for 4 hours and left at room temperature overnight. After concentration in vacuo, 30 ml of water are added to the reaction mixture which is extracted twice with ethyl acetate (20 ml). The aqueous phase is acidified with HCl 1M. The precipate which forms is filtered, air-dried to yield to 1.35 g of 2-(3,5-dichloropyridin-2-yl)cyclopropanecarboxylic acid (87%).

後処理

  1. temperatureis refluxed for 4 hours
  2. concentrationAfter concentration in vacuo, 30 ml of water
  3. additionare added to the reaction mixture which
  4. extractionis extracted twice with ethyl acetate (20 ml)
  5. filtrationThe precipate which forms is filtered
  6. customair-dried

出典と根拠

ORDレコード
ord-b190fc5f0f9644e195ce4514c4cc841c
出典データセット
uspto-grants-2011_12
特許番号
US08071629B2

反応ノート

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