Triphenylphosphine → (3-Bromo-2-methoxyphenyl)methanamine
反応式
[OH-].[K+].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[N:22]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([Br:32])[C:27]=1[O:33][CH3:34])=[N+]=[N-]>C1COCC1.O>[Br:32][C:28]1[C:27]([O:33][CH3:34])=[C:26]([CH:31]=[CH:30][CH:29]=1)[CH2:25][NH2:22]参加物
6
実験手順
1.1 g of potassium hydroxide (KOH) and 5.8 g of triphenyl phophine (Ph3P) were added to a solution of 1-azidomethyl-3-bromo-2-methoxy-benzene 7 in 100 mL of THF and 10 mL of water. The mixture was stirred overnight at room temperature. The mixture was quenched with aqueous concentrated hydrochloride. After standard acid/base aqueous work up, 3.9 g of crude 3-bromo-2-methoxy-benzylamine 8 was obtained (after two steps).
後処理
- customThe mixture was quenched with aqueous concentrated hydrochloride
出典と根拠
- ORDレコード
- ord-85ce9d0e50134564a1c5164e12ba5202
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08071636B2
反応ノート
読み込み中…