Methyl 5-bromoindoline-7-carboxylate → methyl 5-bromo-1H-indole-7-carboxylate
反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:10]=1)[NH:7][CH2:6][CH2:5]2>O1CCCC1.[O-2].[O-2].[Mn+4]>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:10]=1)[NH:7][CH:6]=[CH:5]2参加物
4
実験手順
Methyl 5-bromo-2,3-dihydro-1H-indole-7-carboxylate (6.5 g, 25 mmol) was dissolved in tetrahydrofuran (100 mL). Activated manganese dioxide (5 μm particle size, 22 g, 250 mmol) was added and the mixture stirred at room temperature for 16 hours. A further 22 g of activated manganese dioxide was added and the reaction stirred for 96 hours. The reaction was then filtered through celite and concentrated in vacuo to give 5.1 g (80%) of the title compound as a beige solid.
後処理
- stirringthe reaction stirred for 96 hours
- filtrationThe reaction was then filtered through celite and
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-92feb91ec1944631b25b642e80d6f1d2
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08071584B2
反応ノート
読み込み中…