Lithium Hydroxide → HCID 68652711、化合物
反応式
[CH3:1][O:2][C@H:3]1[CH2:8][O:7][CH2:6][C@@H:5]([C:9]([O:11]C)=[O:10])[CH2:4]1.[Li+].[OH-]>CO>[CH3:1][O:2][C@H:3]1[CH2:8][O:7][CH2:6][C@@H:5]([C:9]([OH:11])=[O:10])[CH2:4]1参加物
4
実験手順
A solution of 10.55 mmol of methyl (cis)-5-methoxytetrahydropyran-3-carboxylate in 45 ml of methanol is mixed with 45 ml of 1M LiOH and stirred at room temperature for one hour. The reaction mixture is evaporated, and the residue is taken up in dichloromethane. The pH is adjusted to 2 with 2M HCl, the phases are separated, and the aqueous phase is extracted with dichloromethane (2×). The combined organic phases are dried with sodium sulphate and evaporated. The crude title compound is identified by means of the Rf from the residue.
後処理
- customThe reaction mixture is evaporated
- customthe phases are separated
- extractionthe aqueous phase is extracted with dichloromethane (2×)
- dry with materialThe combined organic phases are dried with sodium sulphate
- customevaporated
出典と根拠
- ORDレコード
- ord-fb014f64bb7a429485c7400a07d4560c
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08071651B2
反応ノート
読み込み中…