2-(Methylsulfonamido)phenylacetonitrile → N-[2-(2-aminoethyl)phenyl]methanesulfonamide

HRID 656271ノート

反応式

HRID 656271 の反応式
[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][C:13]#[N:14])(=[O:4])=[O:3]>CO.[Pd]>[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][CH2:13][NH2:14])(=[O:4])=[O:3]

参加物

4

反応物 1

HCID 691184052-(Methylsulfonamido)phenylacetonitrile

生成物 1

HCID 20848391N-[2-(2-aminoethyl)phenyl]methanesulfonamide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

(2-Methanesulfonylaminophenyl)acetonitrile (300 mg) was mixed with 10% palladium/carbon (catalytic amount) in methanol (20 ml) and the mixture was stirred under hydrogen gas atmospheres for 48 hours. After confirming the completion of the reaction using TLC, the resulting mixture was filtered through celite and the filtrate was concentrated under reduced pressure. The following procedure was carried out using the concentrate which was not purified.

後処理

  1. filtrationthe resulting mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. concentrationconcentrate which
  4. customwas not purified

出典と根拠

ORDレコード
ord-234744b45fc34bb790657b2e28e616eb
出典データセット
uspto-grants-2011_12
特許番号
US08071650B2

反応ノート

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