Hydroxyamine hydrochloride → N-[(1-methylpyrrol-2-yl)methylidene]hydroxylamine
反応式
[CH3:1][C:2]1C=[CH:5][NH:4][C:3]=1C=O.Cl.[NH2:10][OH:11].[C:12]([O-])(=O)[CH3:13].[Na+]>CO>[CH3:5][N:4]1[CH:3]=[CH:2][CH:1]=[C:12]1[CH:13]=[N:10][OH:11]参加物
5
実験手順
Methyl-2-pyrrolecarboxaldehyde (5 g), hydroxylamine hydrochloride (9.55 g) and sodium acetate (11.28 g) were dissolved in methanol (100 ml) and the solution was refluxed for 12 hours. Aftre confirming the completion of the reaction using TLC, the resulting mixture was purified by column-chromatography (ethyl acetate/hexane=3/1) to yield the compound (5.01 g, 88%) as a brown solid.
後処理
- temperaturethe solution was refluxed for 12 hours
- customthe resulting mixture was purified by column-chromatography (ethyl acetate/hexane=3/1)
出典と根拠
- ORDレコード
- ord-c08aeab8ff784df5a663ac98b5911cdf
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08071650B2
反応ノート
読み込み中…