(1-methyl-1H-pyrrol-2-yl)methanamine → 1-(4-t-butylbenzyl)-3-(1-methyl-1H-pyrrol-2-yl)methylthiourea

HRID 656288

反応式

HRID 656288 の反応式
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][NH2:8].[C:9]([C:13]1[CH:22]=[CH:21][C:16]([CH2:17][N:18]=[C:19]=[S:20])=[CH:15][CH:14]=1)([CH3:12])([CH3:11])[CH3:10]>C(OCC)(=O)C>[C:9]([C:13]1[CH:22]=[CH:21][C:16]([CH2:17][NH:18][C:19]([NH:8][CH2:7][C:3]2[N:2]([CH3:1])[CH:6]=[CH:5][CH:4]=2)=[S:20])=[CH:15][CH:14]=1)([CH3:12])([CH3:10])[CH3:11]

参加物

4

反応物 2

HCID 2776207(1-methyl-1H-pyrrol-2-yl)methanamineHCID 148010411-Tert-butyl-4-(isothiocyanatomethyl)benzene

生成物 1

HCID 590880651-(4-t-butylbenzyl)-3-(1-methyl-1H-pyrrol-2-yl)methylthiourea収率 75.9%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

(1-methyl-1H-pyrrol-2-yl)methylamine (65 mg) and 4-t-butylbenzylisothiocyanate (120 mg) were dissolved in ethyl acetate (30 ml) and the solution was stirred for 12 hours. After the completion of the reaction, the resulting mixture was purified by column-chromatography (ethyl acetate/hexane=1/3) to yield the compound 17-2 (140 mg, 75%)

後処理

  1. customAfter the completion of the reaction
  2. customthe resulting mixture was purified by column-chromatography (ethyl acetate/hexane=1/3)

出典と根拠

ORDレコード
ord-ad0f65674d824e39a75806ea578f636e
出典データセット
uspto-grants-2011_12
特許番号
US08071650B2

関連ノート

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