Phenethyl Isothiocyanate → 1-(1-methyl-1H-pyrrol-2-ylmethyl)-3-phenethylthiourea

HRID 656289ノート

反応式

HRID 656289 の反応式
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][NH2:8].[N:9]([CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[C:10]=[S:11]>C(OCC)(=O)C>[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][NH:8][C:10]([NH:9][CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[S:11]

参加物

4

反応物 2

HCID 16741Phenethyl IsothiocyanateHCID 2776207(1-methyl-1H-pyrrol-2-yl)methanamine

生成物 1

HCID 590880071-(1-methyl-1H-pyrrol-2-ylmethyl)-3-phenethylthiourea収率 60.1%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

(1-methyl-1H-pyrrol-2-yl)methylamine (65 mg) and (2-isothiocyanatoethyl)benzene (100 mg) were dissolved in ethyl acetate (20 ml) and the solution was stirred for 12 hours. After the completion of the reaction, the resulting mixture was purified by column-chromatography (ethyl acetate/hexane=1/3) to yield the compound 17-3 (97 mg, 60%) as a brown liquid.

後処理

  1. customAfter the completion of the reaction
  2. customthe resulting mixture was purified by column-chromatography (ethyl acetate/hexane=1/3)

出典と根拠

ORDレコード
ord-60190a4c30bd418ea67d301a066e7155
出典データセット
uspto-grants-2011_12
特許番号
US08071650B2

反応ノート

読み込み中…