Spiro(5-nitroindane)-2,5'-hydantoin → 5'-Amino-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-2,5-dione
反応式
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[CH2:9][C:8]1([C:16](=[O:17])[NH:15][C:14](=[O:18])[NH:13]1)[CH2:7]2)([O-])=O>CCOC(C)=O.CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[CH2:9][C:8]1([C:16](=[O:17])[NH:15][C:14](=[O:18])[NH:13]1)[CH2:7]2参加物
5
実験手順
To a suspension of (±)-5′-nitro-spiro[imidazolidine-4,2′-indane]-2,5-dione (1.77 g, 7.16 mmol) in EtOAc (100 mL) and MeOH (100 mL) was added 10% Pd/C (400 mg) and the reaction stirred vigorously under hydrogen (ca. 1 atm). After 1 h, the catalyst was filtered off and the filtrate was concentrated to yield the title compound. MS: m/z=218 (M+1).
後処理
- filtrationthe catalyst was filtered off
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-4d38619139b74b08b028cf49b116f538
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08071771B2
反応ノート
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