Nitric Acid → (+/-)-3-Methyl-5'-nitro-spiro[imidazolidine-4,2'-indane]-2,5-dione

HRID 656388ノート

反応式

HRID 656388 の反応式
[N+:1]([O-:4])(O)=[O:2].[CH3:5][N:6]1[C:10]2([CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:11]2)[C:9](=[O:19])[NH:8][C:7]1=[O:20]>O>[CH3:5][N:6]1[C:10]2([CH2:11][C:12]3[C:17](=[CH:16][CH:15]=[C:14]([N+:1]([O-:4])=[O:2])[CH:13]=3)[CH2:18]2)[C:9](=[O:19])[NH:8][C:7]1=[O:20]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 18440308(+/-)-3-Methyl-spiro[imidazolidine-4,2'-indane]-2,5-dione

生成物 1

HCID 18440305(+/-)-3-Methyl-5'-nitro-spiro[imidazolidine-4,2'-indane]-2,5-dione

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To stirred fuming (90%) nitric acid (100 mL) was slowly added (±)-3-methyl-spiro[imidazolidine-4,2′-indane]-2,5-dione (4.5 g, 20.9 mmol) in portions over 30 min. The reaction mixture was diluted with H2O (200 mL) and the precipitate was collected by filtration, washed with H2O and dried in vacuo to give the title compound. MS: m/z=262 (M+1).

後処理

  1. customover 30 min
  2. filtrationthe precipitate was collected by filtration
  3. washwashed with H2O
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-9831e63671604dc19186e7cbb99f12d9
出典データセット
uspto-grants-2011_12
特許番号
US08071771B2

反応ノート

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