Hydrochloric Acid → HCID 68575364、化合物

HRID 656463ノート

反応式

HRID 656463 の反応式
C([N:8]1[CH:13]([C:14]#[N:15])[CH2:12][CH2:11][CH2:10][C:9]1([CH2:18][C:19]([O:21]C(C)(C)C)=[O:20])[C:16]#[N:17])C1C=CC=CC=1.[ClH:26].[H][H]>CO.[Pd]>[ClH:26].[NH2:17][CH2:16][C:9]1([CH2:18][C:19]([OH:21])=[O:20])[CH2:10][CH2:11][CH2:12][CH:13]([CH2:14][NH2:15])[NH:8]1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 86629994HCID 86629994、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 68575364HCID 68575364、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 6.00 mmol of tert-butyl (1-benzyl-2,6-dicyanopiperidin-2-yl)acetate in 40 ml of methanol is admixed with 2 ml of 37% strength aqueous hydrochloric acid and 0.600 g of 10% Pd/C. The reaction mixture is hydrogenated with 4 bar of hydrogen at 22° C. for 18 hours. The reaction mixture is filtered over Hyflo and the filtrate is evaporated. From the residue the crude title compound is identified on the basis of the Rf value. The title compound is used without further purification in the next stage.

後処理

  1. filtrationThe reaction mixture is filtered over Hyflo
  2. customthe filtrate is evaporated
  3. customThe title compound is used without further purification in the next stage

出典と根拠

ORDレコード
ord-e836a627a44e4f1a816e2b1e751d1ee8
出典データセット
uspto-grants-2011_12
特許番号
US08071773B2

反応ノート

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