8-Azidomethyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-ol → 8-Aminomethyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-ol
反応式
[N:1]([CH2:4][C:5]1([OH:14])[CH2:10][CH2:9][CH2:8][N:7]2[CH:11]=[N:12][CH:13]=[C:6]12)=[N+]=[N-].[H][H]>CO.[Pd]>[NH2:1][CH2:4][C:5]1([OH:14])[CH2:10][CH2:9][CH2:8][N:7]2[CH:11]=[N:12][CH:13]=[C:6]12参加物
5
実験手順
3 mmol of 8-azidomethyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-ol are taken up in 10 ml of methanol and the solution is admixed with 0.30 mmol of 10% Pd/C. The reaction mixture is hydrogenated with a hydrogen pressure of 1 bar at 22° C. for 1-10 hours. The catalyst is filtered off over Hyflo and the filtrate is evaporated. From the residue the title compound is identified by means of flash chromatography (SiO2 60 F) on the basis of the Rf value.
後処理
- filtrationThe catalyst is filtered off over Hyflo
- customthe filtrate is evaporated
出典と根拠
- ORDレコード
- ord-c224be4d5dbc49dc838dc34ab96079b0
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08071773B2
反応ノート
読み込み中…