Water → 8-Azidomethyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-8-ol
反応式
[O:1]1[CH2:3][C:2]21[CH2:8][CH2:7][CH2:6][N:5]1[CH:9]=[N:10][CH:11]=[C:4]21.[N-:12]=[N+:13]=[N-:14].[Na+].O>CN(C)C=O>[N:12]([CH2:3][C:2]1([OH:1])[CH2:8][CH2:7][CH2:6][N:5]2[CH:9]=[N:10][CH:11]=[C:4]12)=[N+:13]=[N-:14]参加物
5
反応条件
- 温度
- 60 °C
実験手順
A solution of 5 mmol of 6,7-dihydro-5H-spiro[imidazo[1,5-a]pyridine-8,2′-oxirane] in 15 ml of N,N-dimethylformamide is admixed with 10 mmol of sodium azide and the reaction mixture is heated at 60° C. for 4 hours. The mixture is poured into water and extracted with tert-butyl methyl ether. The combined organic extracts are washed with brine, dried with sodium sulphate and evaporated. From the residue the title compound is identified by means of flash chromatography (SiO2 60 F) on the basis of the Rf value.
後処理
- extractionextracted with tert-butyl methyl ether
- washThe combined organic extracts are washed with brine
- dry with materialdried with sodium sulphate
- customevaporated
出典と根拠
- ORDレコード
- ord-ccc038570b394a97a4903bdc27837725
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08071773B2
反応ノート
読み込み中…