m-Chloroperbenzoic acid → {3-[4-(2,2-Dimethyl-propionylamino)-2-(2-methyl-propane-2-sulfinylmethyl)-phenoxy]-4-methoxy-phenyl}-acetic acid

反応式

[C:1]([S:5][CH2:6][C:7]1[CH:25]=[C:24]([NH:26][C:27](=[O:32])[C:28]([CH3:31])([CH3:30])[CH3:29])[CH:23]=[CH:22][C:8]=1[O:9][C:10]1[CH:11]=[C:12]([CH2:18][C:19]([OH:21])=[O:20])[CH:13]=[CH:14][C:15]=1[O:16][CH3:17])([CH3:4])([CH3:3])[CH3:2].ClC1C=CC=C(C(OO)=[O:41])C=1>>[CH3:29][C:28]([CH3:31])([CH3:30])[C:27]([NH:26][C:24]1[CH:23]=[CH:22][C:8]([O:9][C:10]2[CH:11]=[C:12]([CH2:18][C:19]([OH:21])=[O:20])[CH:13]=[CH:14][C:15]=2[O:16][CH3:17])=[C:7]([CH2:6][S:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[O:41])[CH:25]=1)=[O:32]

参加物

反応物 2

HCID 70297m-Chloroperbenzoic acid

HCID 44600763Am-461

生成物 1

HCID 44600126{3-[4-(2,2-Dimethyl-propionylamino)-2-(2-methyl-propane-2-sulfinylmethyl)-phenoxy]-4-methoxy-phenyl}-acetic acid

実験手順

Prepared according to the procedure described in Example 2 using {3-[2-tert-butylsulfanylmethyl-4-(2,2-dimethyl-propionylamino)-phenoxy]-4-methoxy-phenyl}-acetic acid and 3-chloroperbenzoic acid (1 equivalent).

後処理

customPrepared

出典と根拠

ORDレコード: ord-46084004000c4280a5e219c4e21cbfa2
出典データセット: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08071807B2

反応ノート

読み込み中…