反応式
[CH:1]([C:3]1[C:4]([F:15])=[CH:5][N:6]=[C:7]2[C:12]=1[N:11]=[C:10]([O:13][CH3:14])[CH:9]=[CH:8]2)=[CH2:2].[H][H]>CCO.[Pd]>[CH2:1]([C:3]1[C:4]([F:15])=[CH:5][N:6]=[C:7]2[C:12]=1[N:11]=[C:10]([O:13][CH3:14])[CH:9]=[CH:8]2)[CH3:2]参加物
5
実験手順
8-Ethenyl-7-fluoro-2-(methoxy)-1,5-naphthyridine (for a synthesis see WO2004/058144 Example 53(h)) (1.0 g, 4.90 mmol) was stirred in EtOH (50 ml) with 10% palladium on carbon (0.2 g) and the resulting suspension was hydrogenated under 1 atmosphere of hydrogen pressure for 3 h. The mixture was filtered with suction through celite and the solids were washed with MeOH (500 ml). The combined filtrate plus washings were concentrated to give the title compound as a clear oil (1.045 g, 103%).
後処理
- filtrationThe mixture was filtered with suction through celite
- washthe solids were washed with MeOH (500 ml)
- concentrationThe combined filtrate plus washings were concentrated
出典と根拠
- ORDレコード
- ord-8ed8d834b6114c7e9c80179615375876
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08071592B2
関連ノート
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