Methyl 6-(methyloxy)-1,5-naphthyridine-3-carboxylate → Methyl 6-oxo-5,6-dihydro-1,5-naphthyridine-3-carboxylate

HRID 656920ノート

反応式

HRID 656920 の反応式
C[O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([C:13]([O:15][CH3:16])=[O:14])=[CH:6]2>Br.C(O)(=O)C>[O:2]=[C:3]1[CH:12]=[CH:11][C:10]2[N:9]=[CH:8][C:7]([C:13]([O:15][CH3:16])=[O:14])=[CH:6][C:5]=2[NH:4]1

参加物

4

反応物 1

HCID 68817307Methyl 6-(methyloxy)-1,5-naphthyridine-3-carboxylate

生成物 1

HCID 68818275Methyl 6-oxo-5,6-dihydro-1,5-naphthyridine-3-carboxylate

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 260Hydrogen Bromide溶媒

実験手順

A mixture of methyl 6-(methyloxy)-1,5-naphthyridine-3-carboxylate (1.45 g, 6.65 mmol) in 30% HBr in acetic acid (40 ml) was stirred at rt for 18 h before evaporation and drying in vacuo. The solid was washed with Et2O and dried in vacuo to give the desired product as the dihydrobromide salt (2.425 g, 99%).

後処理

  1. customdrying in vacuo
  2. washThe solid was washed with Et2O
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-4f091e81713d4d5dbac42b43f9893fd8
出典データセット
uspto-grants-2011_12
特許番号
US08071592B2

反応ノート

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