Sodium Hydroxide → Furo[2,3-c]pyridin-5-ylmethanol

HRID 656967ノート

反応式

HRID 656967 の反応式
C([O:4][CH2:5][C:6]1[CH:7]=[C:8]2[CH:14]=[CH:13][O:12][C:9]2=[CH:10][N:11]=1)(=O)C.[OH-].[Na+]>O1CCOCC1.O>[O:12]1[C:9]2=[CH:10][N:11]=[C:6]([CH2:5][OH:4])[CH:7]=[C:8]2[CH:14]=[CH:13]1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 22047292HCID 22047292、化合物

生成物 1

HCID 22047174Furo[2,3-c]pyridin-5-ylmethanol収率 70.2%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

A solution of furo[2,3-c]pyridin-5-ylmethyl acetate (1.15 g) in 1,4-dioxane (30 ml) and water (10 ml) was treated with 2M sodium hydroxide (12 ml) then stirred at ambient temperature for 18 h. The mixture was then partitioned between ethyl acetate and water. The organic fractions were separated and dried then evaporated to dryness. This gave an oil (0.63 g, 70%).

後処理

  1. customThe mixture was then partitioned between ethyl acetate and water
  2. customThe organic fractions were separated
  3. customdried
  4. customthen evaporated to dryness

出典と根拠

ORDレコード
ord-dd3c8144f9af4fc7a42c9df27d594f6a
出典データセット
uspto-grants-2011_12
特許番号
US08071592B2

反応ノート

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