Water → [7-Fluoro-4-(methyloxy)-2-oxo-1(2H)-quinolinyl]acetaldehyde
反応式
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([O:16][CH3:17])=[CH:7][C:8](=[O:15])[N:9]2[CH2:12][CH:13]=C)=[CH:4][CH:3]=1.I([O-])(=O)(=O)=[O:19].[Na+].O>O1CCOCC1.[Os](=O)(=O)(=O)=O>[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([O:16][CH3:17])=[CH:7][C:8](=[O:15])[N:9]2[CH2:12][CH:13]=[O:19])=[CH:4][CH:3]=1参加物
6
実験手順
A solution of 7-fluoro-4-(methyloxy)-1-(2-propen-1-yl)-2(1H)-quinolinone (0.386 g, 1.66 mmol), sodium periodate (0.83 g, 3.7 mmol) and osmium tetroxide (1.7 ml, 4% in water) in 1,4-dioxane (15 ml) containing water (3 ml) was stirred for 5 h. The mixture was separated between dichloromethane and water. The organics were isolated, dried and concentrated to provide the title compound (0.364 g, 93%).
後処理
- customThe mixture was separated between dichloromethane and water
- customThe organics were isolated
- customdried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-4befbd37fc2546b69f661405ac5f9316
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08071592B2
反応ノート
読み込み中…