HCID 86635367、化合物 → HCID 68809399、化合物
反応式
[OH:1][C@@H:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][N:10]2[C:15](=[O:16])[CH:14]=[N:13][C:12]3[CH:17]=[CH:18][C:19]([O:21][CH3:22])=[N:20][C:11]2=3)[CH2:4][C@@H:3]1[CH2:23][NH:24]C(=O)OCC1C=CC=CC=1>CCO.[OH-].[OH-].[Pd+2]>[NH2:24][CH2:23][C@@H:3]1[C@H:2]([OH:1])[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][N:10]2[C:15](=[O:16])[CH2:14][NH:13][C:12]3[CH:17]=[CH:18][C:19]([O:21][CH3:22])=[N:20][C:11]2=3)[CH2:4]1参加物
4
実験手順
To a solution of phenylmethyl [((3S,4R)-4-hydroxy-1-{2-[6-(methyloxy)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl]ethyl}-3-piperidinyl)methyl]carbamate (234 mg; 0.502 mmol) in EtOH was added 20% Pd(OH)2/C (100 mg). The mixture was hydrogenated at 1 atm of H2 at ambient temperature overnight. The crude product was filtered through Celite, washed with ethanol and concentrated under reduced pressure to obtain the product (170 mg; 100%)