Tert-butyl 4-(3-bromobenzylidene)piperidine-1-carboxylate → Tert-butyl 4-(3-bromobenzyl)piperidine-1-carboxylate
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)[CH:5]=[CH:6][CH:7]=1>C1COCC1>[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)[CH:5]=[CH:6][CH:7]=1参加物
3
実験手順
To a solution of 1,1-dimethylethyl 4-[(3-bromophenyl)methylidene]-1-piperidine-carboxylate (201 mg, 0.571 mmol) in THF (1 mL) was applied onto an H-Cube hydrogenation device (H-Cube, LLC, Dallas, Tex., USA; http://www.h-cubeinc.com/) 10% PD/C at a flow rate of 1 mL/min and 1 atm H2. The mixture was concentrated to afford the title compound 0.1909 g (94%). LC-MS m/z 354 (M+H)+.
後処理
- concentrationThe mixture was concentrated