Benzoic Acid → 5-Hydroxypentyl benzoate
反応式
[C:1]([OH:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:10](O)[CH2:11][CH2:12][CH2:13][CH2:14][OH:15].C1(C)C=CC(S(O)(=O)=O)=CC=1>O>[C:1]([O:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][OH:15])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
5
反応条件
- 温度
- 100 °C
実験手順
A mixture of benzoic acid (1 g), 1,5-pentanediol (5 mL) and p-toluenesulfonic acid (110 mg) was heated in an oil-bath at 100° C. overnight. The reaction mixture was cooled to room temperature, poured into water (50 mL) and extracted with EtOAc (2×25 mL), washed with sodium carbonated (5%, 20 mL) followed by brine (15 mL). The organic layer was dried over anhyd. sodium sulfate, filtered and concentrated to give almost pure product (1.15 g, 67%);
後処理
- temperatureThe reaction mixture was cooled to room temperature
- extractionextracted with EtOAc (2×25 mL)
- washwashed with sodium
- customThe organic layer was dried over anhyd
- filtrationsodium sulfate, filtered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-155d34d436e840d59a60ff2dac6381b7
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08076303B2
反応ノート
読み込み中…