Oxalyl chloride → HCID 22344169、化合物

HRID 657606ノート

反応式

HRID 657606 の反応式
C(Cl)(=O)C([Cl:4])=O.[ClH:7].[C:8](O)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>ClCCl.CN(C)C=O>[ClH:4].[C:8]([Cl:7])(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 57447319Benzoate hydrochloride

生成物 1

HCID 22344169HCID 22344169、化合物

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

Oxalic chloride (800 μL) is added dropwise to a solution of 4-[3-(cis and trans-3,5-dimethylpiperidino)propoxy]benzoic acid, hydrochloride (2.33 g) in dichloromethane (20 mL) containing one drop of N,N-dimethylformamide. The mixture is stirred for two hours at room temperature and concentrated under reduced pressure. Cyclohexane is added and evaporated under reduced pressure to afford 2.55 g of 4-[3-(cis and trans-3,5-dimethylpiperidino)propoxy]benzoyl chloride, hydrochloride used without further purification.

後処理

  1. concentrationconcentrated under reduced pressure
  2. additionCyclohexane is added
  3. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-a5d8d981dcbb4d4db2bba4785c0821a8
出典データセット
uspto-grants-2011_12
特許番号
US08076329B2

反応ノート

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