Acetonitrile → Ranisen

HRID 65765

反応式

HRID 65765 の反応式
[CH3:1][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][S:11][CH2:12][CH2:13][NH2:14])=[CH:7][CH:6]=1)[CH3:3].CS[C:17](SC)=[CH:18][N+:19]([O-:21])=[O:20].[C:24](#[N:26])C>>[CH3:3][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:17]([NH:26][CH3:24])=[CH:18][N+:19]([O-:21])=[O:20])=[CH:7][CH:6]=1)[CH3:1]

参加物

4

反応物 3

HCID 6342AcetonitrileHCID 836231,1-Bis(methylthio)-2-nitroethyleneHCID 1622035-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine

生成物 1

HCID 5039Ranisen

実験手順

2-[[[5-(Dimethylamino)methyl-2-furanyl]methyl]thio]ethanamine (4.25 g) and 1,1-bis(methylthio)-2-nitroethene (3.3 g) were refluxed in acetonitrile (50 ml) for 14 hr. Solvent was removed and the residue dissolved in 36% methanolic methylamine (50 ml) and the solution refluxed for 8 hr. Solvents were removed and the residue in methanol treated with charcoal. Filtration and evaporation of the solvent gave the title compound as Example 15 (5.0 g).

後処理

  1. customSolvent was removed
  2. dissolutionthe residue dissolved in 36% methanolic methylamine (50 ml)
  3. temperaturethe solution refluxed for 8 hr
  4. customSolvents were removed
  5. additionthe residue in methanol treated with charcoal
  6. filtrationFiltration and evaporation of the solvent

出典と根拠

ORDレコード
ord-590ae28d589b41ae960292662b4c4b89
出典データセット
uspto-grants-1978_12
特許番号
US04128658

関連ノート

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