Hydrogen Bromide → 2-Chloro-4-(4-hydroxyphenyl)pyridine hydrobromide

HRID 657667ノート

反応式

HRID 657667 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([O:14]C)=[CH:10][CH:9]=2)[CH:5]=[CH:4][N:3]=1.[BrH:16]>>[BrH:16].[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:9]=[CH:10][C:11]([OH:14])=[CH:12][CH:13]=2)[CH:5]=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 260Hydrogen BromideHCID 534408782-Chloro-4-(4-methoxyphenyl)pyridine

生成物 1

HCID 1363359722-Chloro-4-(4-hydroxyphenyl)pyridine hydrobromide

実験手順

A mixture of 2-chloro-4-(4-methoxyphenyl)pyridine (4.6 g) and 48% aqueous hydrobromic acid solution is heated under reflux for 3.5 hours and allowed to cool back to room temperature. The precipitate that appears is separated by filtration, washed with water and dried under reduced pressure to give 4.9 g of 2-chloro-4-(4-hydroxyphenyl)pyridine hydrobromide as a yellow solid used without further purification.

後処理

  1. temperatureis heated
  2. temperatureunder reflux for 3.5 hours
  3. customThe precipitate that appears is separated by filtration
  4. washwashed with water
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-8f8d494fbdab474f8a02b5649782bc73
出典データセット
uspto-grants-2011_12
特許番号
US08076329B2

反応ノート

読み込み中…