(R)-6-Benzyl-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine → (R)-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

HRID 657782ノート

反応式

HRID 657782 の反応式
C([N:8]1[CH2:30][CH2:29][C:11]2[N:12]=[CH:13][N:14]=[C:15]([NH:16][C@@H:17]([C:19]3[CH:20]=[N:21][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:23][CH:24]=3)[CH3:18])[C:10]=2[CH2:9]1)C1C=CC=CC=1>[Pd].CO>[F:28][C:25]([F:26])([F:27])[C:22]1[N:21]=[CH:20][C:19]([C@H:17]([NH:16][C:15]2[C:10]3[CH2:9][NH:8][CH2:30][CH2:29][C:11]=3[N:12]=[CH:13][N:14]=2)[CH3:18])=[CH:24][CH:23]=1

参加物

4

反応物 1

HCID 59840708(R)-6-Benzyl-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

生成物 1

HCID 59840692(R)-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine収率 98.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of (R)-6-benzyl-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine (3.55 g, 8.59 mmol), 10% palladium on charcoal (740 mg), and methanol (60 mL) were stirred under hydrogen (1 atm) for 15 h. The catalyst was filtered off through Celite and the filter cake was washed with MeOH (3×30 mL). The filtrate was concentrated to obtain an off-white foam (2.74 g, 98% yield).

後処理

  1. filtrationThe catalyst was filtered off through Celite
  2. washthe filter cake was washed with MeOH (3×30 mL)
  3. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-76b044b0dd6b41dbbafce2f1e6f88750
出典データセット
uspto-grants-2011_12
特許番号
US08076345B2

反応ノート

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