Glutaric Acid → HCID 178484388、化合物
反応式
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[OH-].[Na+].[C:12]([OH:20])(=[O:19])[CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17].C(Cl)Cl>C(O)C>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:12]([O-:20])(=[O:19])[CH2:13][CH2:14][CH2:15][C:16]([O-:18])=[O:17]参加物
6
実験手順
10.0 g of metformin, 2.40 g of sodium hydroxide and 3.98 g of glutaric acid were stirred in 150 ml of ethyl alcohol at a temperature of 70° C., and then methylene chloride was added thereto. The produced inorganic salt was filtered and ethyl acetate was added to the filtered solution. The produced crystal was filtered and dried in hot air, thus obtaining 6.79 g (yield: 57.7%) of metformin glutarate.
後処理
- filtrationThe produced inorganic salt was filtered
- additionethyl acetate was added to the filtered solution
- filtrationThe produced crystal was filtered
- customdried in hot air
出典と根拠
- ORDレコード
- ord-ecf0fa3b2337412185e3c44166b38cbb
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08076377B2
反応ノート
読み込み中…