Adipic Acid → HCID 178484387、化合物
反応式
[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].Cl.[OH-].[Na+].[C:13]([OH:22])(=[O:21])[CH2:14][CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19].C(Cl)Cl>C(O)C>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:13]([O-:22])(=[O:21])[CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O-:20])=[O:19]参加物
6
実験手順
10.00 g of metformin hydrochloride, 2.40 g of sodium hydroxide and 2.20 g of adipic acid were stirred in 150 ml of ethyl alcohol at 70° C., and then methylene chloride was added thereto. Then, the produced inorganic salt was filtered, and ethyl acetate was added to the filtrate. The produced crystal was filtered and dried in hot air, thus obtaining 4.90 g (yield: 80.5%) of metformin adipate.
後処理
- filtrationThen, the produced inorganic salt was filtered
- additionethyl acetate was added to the filtrate
- filtrationThe produced crystal was filtered
- customdried in hot air
出典と根拠
- ORDレコード
- ord-6a57b952a08b47e2ab3e40695d305e26
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08076377B2
反応ノート
読み込み中…