(S)-(5-Isobutyl-indan-2-yl)-carbamic acid benzyl ester → (S)-5-Isobutyl-indan-2-ylamine
反応式
C(OC(=O)[NH:10][C@@H:11]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([CH2:20][CH:21]([CH3:23])[CH3:22])[CH:17]=2)[CH2:12]1)C1C=CC=CC=1>CO.[Pd]>[CH2:20]([C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[CH2:12][C@H:11]([NH2:10])[CH2:19]2)[CH:21]([CH3:23])[CH3:22]参加物
4
実験手順
(S)-(5-Isobutyl-indan-2-yl)-carbamic acid benzyl ester ( ) is dissolved in methanol (100 ml), 10% Pd—C (200 mg) is added and the flask is purged with H2(g) (0.35 bar). The reaction mixture is stirred for 18 hours, the catalyst is filtered off. The solvent is removed in vacuo to give title compound. 1H nmr (CDCl3, 400 MHz); 7.10 (d, 1H), 7.00 (s, 1H), 6.90 (d, 1H), 3.85 (m, 1H), 3.15 (dd, 2H), 2.65 (dt, 2H), 2.45 (d, 2H), 1.80 (br m, 3H), 0.90 (d, 6H).
後処理
- customthe flask is purged with H2(g) (0.35 bar)
- filtrationthe catalyst is filtered off
- customThe solvent is removed in vacuo
出典と根拠
- ORDレコード
- ord-708b1d64f8ef48c5bba09818ad6390db
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08076489B2
反応ノート
読み込み中…