(R)-(+)-1,1,1-trifluoro-2-octyl 4-benzyloxybenzoate → 4-hydroxybenzoic acid (R)-1-trifluoromethyl-heptyl ester

HRID 6587

反応式

HRID 6587 の反応式
C([O:8][C:9]1[CH:28]=[CH:27][C:12]([C:13]([O:15][C@@H:16]([C:23]([F:26])([F:25])[F:24])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[O:14])=[CH:11][CH:10]=1)C1C=CC=CC=1>C(OCC)(=O)C>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]([O:15][C@@H:16]([C:23]([F:24])([F:25])[F:26])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[O:14])=[CH:27][CH:28]=1

参加物

3

反応物 1

HCID 22850730(R)-(+)-1,1,1-trifluoro-2-octyl 4-benzyloxybenzoate

生成物 1

HCID 145492174-hydroxybenzoic acid (R)-1-trifluoromethyl-heptyl ester収率 99%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

2.2 g of [R]-1-trifluoromethylheptyl 4-benzyloxybenzoate, (13) 100 mg of PdOH/C in 50 ml of ethyl acetate was stirred at RT over night under H2 atmosphere. Then the catalyst was filtered out and filtrate was evaporated to dryness to give the pure compound in yield of 99%.

後処理

  1. filtrationThen the catalyst was filtered out
  2. customfiltrate was evaporated to dryness
  3. customto give the pure compound in yield of 99%

出典と根拠

ORDレコード
ord-3687b0a5c976428fb52ff00b4203cdb7
出典データセット
uspto-grants-2006_08
特許番号
US07083832B2

関連ノート

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