Hydrochloric Acid → 2-(3-Bromobenzyloxy)ethanol
反応式
CC(C[AlH]CC(C)C)C.[Br:10][C:11]1[CH:12]=[C:13]([CH:17]2[O:21][CH2:20][CH2:19][O:18]2)[CH:14]=[CH:15][CH:16]=1.Cl>CCCCCCC>[Br:10][C:11]1[CH:12]=[C:13]([CH:14]=[CH:15][CH:16]=1)[CH2:17][O:18][CH2:19][CH2:20][OH:21]参加物
5
実験手順
A solution of DIBAL-H in heptane is added under an inert atmosphere to a cooled (−78° C.) solution of 2-(3-bromophenyl)-1,3-dioxolane in hexanes. The reaction mixture is stirred until no starting material is seen by TLC. Aqueous HCl (1N) is added to the reaction mixture while warming to room temperature. The product is extracted with EtOAc. Combined organic layers are dried over anhydrous MgSO4, and concentrated under reduced pressure to give 2-(3-bromobenzyloxy)ethanol.
後処理
- extractionThe product is extracted with EtOAc
- dry with materialCombined organic layers are dried over anhydrous MgSO4
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-d6290984b23c4033b0818dc1a9a1c022
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08076516B2
反応ノート
読み込み中…