3-(Trifluoromethyl)phenyl isocyanate → 1-[4-(6-Methylsulfanyl-pyrimidin-4-yloxy)-phenyl]-3-(3-trifluoromethyl-phenyl)-urea

HRID 659028ノート

反応式

HRID 659028 の反応式
[CH3:1][S:2][C:3]1[N:8]=[CH:7][N:6]=[C:5]([O:9][C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH:4]=1.[F:17][C:18]([F:29])([F:28])[C:19]1[CH:20]=[C:21]([N:25]=[C:26]=[O:27])[CH:22]=[CH:23][CH:24]=1>C1COCC1>[CH3:1][S:2][C:3]1[N:8]=[CH:7][N:6]=[C:5]([O:9][C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:26]([NH:25][C:21]3[CH:22]=[CH:23][CH:24]=[C:19]([C:18]([F:17])([F:28])[F:29])[CH:20]=3)=[O:27])=[CH:12][CH:11]=2)[CH:4]=1

参加物

4

反応物 2

HCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 675239014-(6-Methylsulfanyl-pyrimidin-4-yloxy)-phenylamine

生成物 1

HCID 675239161-[4-(6-Methylsulfanyl-pyrimidin-4-yloxy)-phenyl]-3-(3-trifluoromethyl-phenyl)-urea収率 76.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of 4-(6-methylsulfanyl-pyrimidin-4-yloxy)-phenylamine (1.3 g, 5.5 mmol) in THF (24 ml) is cooled to 0° C. A solution of 3-(trifluoromethyl)phenyl isocyanate (790 μl, 5.5 mmol) in THF (24 ml) is added and stirring is continued overnight at r.t. The solvent is evaporated and the crude product is purified by silica gel chromatography using an ethyl acetate/heptane eluent (1:1) to give 1.76 g (75%) of a white powder.

後処理

  1. customThe solvent is evaporated
  2. customthe crude product is purified by silica gel chromatography

出典と根拠

ORDレコード
ord-989e36c012ac4987971902c61af8de1c
出典データセット
uspto-grants-2011_12
特許番号
US08080552B2

反応ノート

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