Triethylamine → Imidazole-1-carboxylic acid bicyclo[1.1.1]pent-1-ylamide

HRID 659042ノート

反応式

HRID 659042 の反応式
C(N(CC)CC)C.Cl.[C:9]12([NH2:14])[CH2:13][CH:11]([CH2:12]1)[CH2:10]2.[C:15](N1C=CN=C1)([N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1)=[O:16]>CN(C=O)C>[C:9]12([NH:14][C:15]([N:17]3[CH:21]=[CH:20][N:19]=[CH:18]3)=[O:16])[CH2:13][CH:11]([CH2:12]1)[CH2:10]2

参加物

5

反応物 3

HCID 8471TriethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 54589873Bicyclo[1.1.1]pentan-1-amine hydrochloride

生成物 1

HCID 59191971Imidazole-1-carboxylic acid bicyclo[1.1.1]pent-1-ylamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Triethylamine (0.1 mL, 0.5 mmol) was added to a solution of bicyclo[1.1.1]-pentan-1-amine hydrogen chloride (19 mg, 0.16 mmol) and 1,1′-carbonyldiimidazole (32 mg, 0.192 mmol) in DMF (2 mL) (clear solution turned into suspension). The suspension was used for the synthesis of compound 1 without further isolation of compound 1b.

出典と根拠

ORDレコード
ord-87b560074e7d490794af82b5a7cf6430
出典データセット
uspto-grants-2011_12
特許番号
US08080556B2

反応ノート

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