化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → 5-Benzoylfuran-2-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 5-Benzoyl-furan-2-carboxylic acid methyl ester | HCID 10775790 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 5-Benzoylfuran-2-carboxylic acid | HCID 2877255 | — |
反応手順
The crude ester (8) (80 mg, 0.35 mmol) was hydrolysed using Method C, except that MeOH (0.8 mL) and 1 M NaOH (0.8 mL) were used. After the reaction, the solvent was removed under a stream of nitrogen gas, acidified using 1N HCl, extracted with EtOAc, dried (MgSO4), filtered and the solvent concentrated in vacuo to give the crude title compound. Yield: 48 mg; HPLC Purity: >66%; LC tr 0.09 min
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08080567B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-24296fc598344a6baed41b0f03dc3459 |
| 出典メモ | uspto-grants-2011_12 |